American Society of Hematology

Fig. 5.

$Fig. 5. Role of TNF, IFN, and IL-10 in LPS effects on CXCR4 and CCR5 expression on CD4+ T cells. / Whole blood was incubated with LPS (10 ng/mL) and cytokine or control (10 μg/mL) mAbs or recombinant cytokines (10 ng/mL) for 8 hours. Upper panels: effect of anti-TNF, anti-IFNγ, and anti–IL-10 on LPS-induced effects. *P < .05 compared with LPS+IgG (irrelevant control). Lower panels: effects of recombinant TNF, IFNγ, and IL-10. Data represent the fraction of CD4+ T cells that stained positive for either CXCR4 or CCR5. Similar results were obtained for either CXCR4 or CCR5. *P < .05 compared with RPMI.$

Role of TNF, IFN, and IL-10 in LPS effects on CXCR4 and CCR5 expression on CD4⁺ T cells.

Whole blood was incubated with LPS (10 ng/mL) and cytokine or control (10 μg/mL) mAbs or recombinant cytokines (10 ng/mL) for 8 hours. Upper panels: effect of anti-TNF, anti-IFNγ, and anti–IL-10 on LPS-induced effects. *P < .05 compared with LPS+IgG (irrelevant control). Lower panels: effects of recombinant TNF, IFNγ, and IL-10. Data represent the fraction of CD4⁺ T cells that stained positive for either CXCR4 or CCR5. Similar results were obtained for either CXCR4 or CCR5. *P < .05 compared with RPMI.

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