Effects of IFN, As, and their combination on the expression of IκB-α, bcl-2, and p53 in HuT-102 cells treated for 48 hours with IFN and/or As.

For IκB-α expression, the upper band (large arrow) represents the 36-kd major IκB-α protein, also observed in CEM cells (not shown). The lower bands of 34 and 32 kd (small arrows) presumably represent N-terminal proteolytic forms of IκB-α 48 up-regulated by As-IFN treatment.