Model for the involvement of syntaxin 6 and SNAP-23 in neutrophil exocytosis.

This schematic diagram is designed to portray a currently plausible mechanism for the involvement of syntaxin 6 and SNAP-23 in the human neutrophil exocytosis. Interaction of both proteins, acting as t- and v-SNAREs, provides specificity to the fusion process. Exocytosis of specific granules is mediated by interaction of syntaxin 6 with SNAP-23, whereas exocytosis of azurophilic granules would involve interaction of syntaxin 6 with a still unknown structure (denoted as “?”). See text for further details.