Typical alterations of lethally irradiated recipient mice reconstituted with Stat5a/b-deficient

bcr-abl-infected bone marrow. (A) Macroscopic appearance of the lungs. Note the punctuated bleedings associated with focal accumulation of myeloid cells. (B) Macroscopic appearance of the spleen. Note the loss of normal splenic architecture produced by the nodular sites of tumor. (C) Histologic section of a spleen stained with hematoxylin-eosin (HE). Extramedullary hematopoiesis and focal accumulations of tumor cells are evident. (D) Histologic section of a liver stained with HE demonstrates the perivascular accumulation of infiltrating myeloid cells. (E) Blood smear (top) and FACS analysis (bottom) of a myeloid lineage tumor. (F) Blood smear (top) and FACS analysis (bottom of a lymphoid lineage tumor).