Increases in Hb after treatment with CGP57148B.

CGP57148B (CGP) increases intracellular Hb levels and CD11b expression in HL-60/Bcr-Abl and K562 cells. Following treatment with 0.25 μmol/L CGP, 10 nmol/L Ara-C or CGP plus Ara-C for 7 days, intracellular Hb levels and CD11b expression were determined in HL-60/Bcr-Abl and K562 cells (see text). Values represent the means of 3 separate experiments.