Fig. 4.
CGP57148B (CGP) inhibits tyrosine phosphorylation of proteins and down-regulates Bcl-xL in HL-60/Bcr-Abl and K562 cells.
Cells were treated with 0.25 μmol/L CGP for 24 to 72 hours, cellular proteins were extracted and Western analyses of Bcr-Abl, Abl, Bcl-xL, Bax, β-actin, as well as tyrosine phosphorylated proteins (P-Tyr) were performed (see text). Expression levels are representative of 3 separate experiments.
