Fig. 5.
Fig. 5. Analysis of VH constant region transcripts from case 5184. / LHJH sequences are shown from FWR3 for reference. Transcripts for IgM, IgD, IgG1, and IgA were detected using a CDR3-specific primer together with constant region primers. As for case 5049, IgG1 sequences diverged from the IgM/D population. Mutations in codons 105 and 106 were shared with the α-transcripts, perhaps indicating a second switch event in a cell population that had switched from IgM/D to IgG1. The figure presents the 33 sequences that were analyzed. Constant region sequences are not shown.

Analysis of VH constant region transcripts from case 5184.

LHJH sequences are shown from FWR3 for reference. Transcripts for IgM, IgD, IgG1, and IgA were detected using a CDR3-specific primer together with constant region primers. As for case 5049, IgG1 sequences diverged from the IgM/D population. Mutations in codons 105 and 106 were shared with the α-transcripts, perhaps indicating a second switch event in a cell population that had switched from IgM/D to IgG1. The figure presents the 33 sequences that were analyzed. Constant region sequences are not shown.

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