Fig. 3.
Fig. 3. Analysis of VH constant region transcripts from case 5049. / Alignment is made to the closest germline gene segments V4-34 and JH4a and to the LHJH sequences. Using VH primers together with constant region primers specific for IgM, IgD, IgG, and IgA, transcripts for IgM, IgD, IgG1, IgG3, and IgA were identified. Mutational patterns indicated 2 distinct clusters of transcripts: IgM/D, IgG3, and IgA on one hand and IgG1 and IgA on the other. Only nonidentical sequences are shown; the numbers at the left of each line indicate the frequency of the repeated sequences. Constant region sequences are not shown. In total, 59 tumor-related sequences were analyzed.

Analysis of VH constant region transcripts from case 5049.

Alignment is made to the closest germline gene segments V4-34 and JH4a and to the LHJH sequences. Using VH primers together with constant region primers specific for IgM, IgD, IgG, and IgA, transcripts for IgM, IgD, IgG1, IgG3, and IgA were identified. Mutational patterns indicated 2 distinct clusters of transcripts: IgM/D, IgG3, and IgA on one hand and IgG1 and IgA on the other. Only nonidentical sequences are shown; the numbers at the left of each line indicate the frequency of the repeated sequences. Constant region sequences are not shown. In total, 59 tumor-related sequences were analyzed.

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