Comparison of the full-length form of hMgcRacGAP and mMgcRacGAP.

(A) The amino acid sequences of the full-length form of hMgcRacGAP (upper line) and mMgcRacGAP (lower line) were deduced from the open reading frames detected in cDNAs. Amino acid sequences that are related to the 3 consensus active site boxes of RhoGAPs are indicated by brackets. Boxed sequences in a dotted line indicate the cysteine-rich regions in which cysteine and histidine residues are conserved in similar regions of chimaerins and protein kinase C. Amino acid sequences that are related to a myosin-like motif are boxed in a straight line. (B) Alignment of the myosin-like domains of the full-length form of hMgcRacGAP, mMgcRacGAP, and tropomyosins (TPM). Homologous residues in myosin-like motif are boxed.