Fig. 7.
Fig. 7. CAAL-based inhibitors of GGTase I. / GGTase I catalyzes the geranylgeranylation of proteins terminating with CAAX sequences where X is restricted to leucine, isoleucine or, to a lesser extent, phenylalanine. In cells, geranylgeranylation of proteins is far more common than farnesylation. Proteins modified by GGTase I include Rap1A, Rap1B, Rac1, Rac2, G25K, and RhoA.

CAAL-based inhibitors of GGTase I.

GGTase I catalyzes the geranylgeranylation of proteins terminating with CAAX sequences where X is restricted to leucine, isoleucine or, to a lesser extent, phenylalanine. In cells, geranylgeranylation of proteins is far more common than farnesylation. Proteins modified by GGTase I include Rap1A, Rap1B, Rac1, Rac2, G25K, and RhoA.

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