Fig. 6.
Fig. 6. IL-4 induces the survival of BMMCs through γc- and Jak3-dependent signaling. / BMMCs from WT, γc−, and Jak3−mice were cultured in the absence of IL-3 for 5 days, and cell viability was determined by FACS using PI (5 μg/mL) at days 0, 1, 3, and 5. Where indicated, recombinant murine IL-4 or recombinant murine IL-13 was added at 20 ng/mL. Data are means ± SD for 5 mice in each group. The mean value of IL-4–stimulated BMMCs is significantly different from the mean value of control BMMCs in WT mice. *P < .001.

IL-4 induces the survival of BMMCs through γc- and Jak3-dependent signaling.

BMMCs from WT, γc−, and Jak3−mice were cultured in the absence of IL-3 for 5 days, and cell viability was determined by FACS using PI (5 μg/mL) at days 0, 1, 3, and 5. Where indicated, recombinant murine IL-4 or recombinant murine IL-13 was added at 20 ng/mL. Data are means ± SD for 5 mice in each group. The mean value of IL-4–stimulated BMMCs is significantly different from the mean value of control BMMCs in WT mice. *P < .001.

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