Fig. 5.
![Fig. 5. IL-4 induces the proliferation of BMMCs through γc- and Jak3-dependent signaling. / BMMCs from WT, γc−, and Jak3−mice were cultured in the presence of IL-3 for 36 hours, with [3H] thymidine added for the final 12 hours. Where indicated, recombinant murine IL-4 or recombinant murine IL-13 was added at 20 ng/mL. Data are means ± SD for 5 mice in each group. The mean value of IL-4–stimulated BMMCs is significantly different from the mean value of control BMMCs (IL-3 alone) in WT mice. *P < .005.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/96/6/10.1182_blood.v96.6.2172/5/h81800149005.jpeg?Expires=1724228182&Signature=kL9Bb5ttyL9q2YWa80diDafXjzlZQLm5197lXNyStiQPed~l4Ey5-LLpx1NsdhCuYJCvui2FedRhOuHdGxnn~eleFpj~jgpw3uMfilbgjSVlRObZlF0etSlKuDwYSsgUj7dFjXI1kwffWqlJX~ONb8aCGtggscC3R9j86um0g0l5UAfm2Eu2VL0lWcSf06zHQeckpLxBgLz5gTdUpN1wrulMBum5KYiCBLydowq~3gMKiI9AF1ee66xrVro3UTvHadLZkBm1xoQAHZBKBwS4Qbc4DtV-QBpE02oP-bw6V85Bm5qL1Y6B8jiaidCfmnTZfNCSEt1O0Xj9ZiKVb8Llgw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
IL-4 induces the proliferation of BMMCs through γc- and Jak3-dependent signaling.
BMMCs from WT, γc−, and Jak3−mice were cultured in the presence of IL-3 for 36 hours, with [3H] thymidine added for the final 12 hours. Where indicated, recombinant murine IL-4 or recombinant murine IL-13 was added at 20 ng/mL. Data are means ± SD for 5 mice in each group. The mean value of IL-4–stimulated BMMCs is significantly different from the mean value of control BMMCs (IL-3 alone) in WT mice. *P < .005.
