Comparison of human and canine vWF amino acid sequence.

The protein sequence of human vWF is similar to canine vWF. The continuous amino acid sequence of human pre-pro-vWF is shown, with the differences in the canine sequence below. Conserved residues are represented by a dot, conservative substitutions are shown as lowercase letters, and nonconservative substitutions are shown as capital letters. The 234 cysteine residues, all of which are conserved, are underlined. Signal peptide and propeptide cleavage sites are represented by ↓ symbols. Canine AgII has an RGD sequence beginning at residue 531, in addition to the residues at amino acids 698 in AgII and 2507 in mature vWF, which exist in both the human and canine proteins.