Effect of L-NMMA on the induction of the wild-type and mutated GATA motifs of the Epo promoter with Luc reporter constructs in Hep3B cells.

Wild-type (Δ18pXP2) and mutated (Δ18m7pXP2) GATA motifs. Hypoxic induction of Luc gene expression is represented as a hypoxia/normoxia ratio. Fold induction indicates this hypoxia/normoxia ratio. Four separate experiments (duplicate sample) were performed (n = 4). Error bars represent 1 SD. *P < .01.