Differences in fibrinogen binding of platelet suspensions prepared from wild-type (+/+), heterozygous (+/−), and homozygous (−/−) mice.

Filled boxes represent nonstimulated platelets, and striped boxes represent platelets stimulated with 10 μmol/L ADP. Platelets were incubated with 40 μg/mL labeled fibrinogen for 25 minutes at 22°C. Results represent specific fibrinogen binding. Nonspecific binding was evaluated on separate mice because of the scarcity of the platelet sample drawn from each animal.