Sequence and structure of oligodeoxynucleotides.

(A) Abbreviated names, sequence, and internucleoside linkages of all oligodeoxynucleotides used in this study. Target positions of oligonucleotides within the mRNA of Mcl-1 (ORF 61-1110) and TNF-α (ORF 86-787) are shown in brackets below each oligodeoxynucleotide name. F∼ = 5(6)carboxyfluorescein-aminohexanol linkage, / = phosphodiester internucleoside linkage, and − = methylphosphonate internucleosidal linkage. (B) Schematic showing chimeric phosphodiester/methylphosphonate oligodeoxynucleotide structure.