Fig. 7.
Fig. 7. Proposed model of adhesion of LS174T cells to surface-immobilized platelets under dynamic flow conditions via 2 distinct pathways. / (1a) Platelet P-selectin mediates LS174T cell tethering/rolling, and (1b) subsequent platelet αIIbβ3 involvement converts these transient interactions into stable adhesion. (2) Platelet αIIbβ3-integrins can directly capture and instantaneously stabilize free-flowing LS174T cells at low shear stress conditions. The sLex-bearing COLO205 cells follow the sequential cascade of adhesive interactions outlined in pathway 1, whereas the attachment of sLex-negative HCT-8 cells to platelets is described by pathway 2.

Proposed model of adhesion of LS174T cells to surface-immobilized platelets under dynamic flow conditions via 2 distinct pathways.

(1a) Platelet P-selectin mediates LS174T cell tethering/rolling, and (1b) subsequent platelet αIIbβ3 involvement converts these transient interactions into stable adhesion. (2) Platelet αIIbβ3-integrins can directly capture and instantaneously stabilize free-flowing LS174T cells at low shear stress conditions. The sLex-bearing COLO205 cells follow the sequential cascade of adhesive interactions outlined in pathway 1, whereas the attachment of sLex-negative HCT-8 cells to platelets is described by pathway 2.

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