Effect of IL-15 on chemotaxis and fungicidal activity of PMNs from healthy controls (black columns) and patients (gray columns) with untreated advanced HIV infection.

(A) PMNs were incubated with IL-15 (10 ng/mL) or medium alone for 6 hours and then tested for their ability to migrate in a blind-well chamber toward fMLPB as chemoattractant. (B) PMNs were incubated with medium alone, IL-15 (10 ng/mL) or IFN-γ (500 U/mL) for 6 hours and then assayed for killing activity against Candida by the methylene blue staining technique. Results are expressed as mean ± SEM. Asterisks indicate a significant increase in PMN chemotaxis and fungicidal activity (P < .05).