Serum cathepsin activities in patients with Gaucher disease before and after enzyme replacement therapy.

Serum samples from 6 patients with type I Gaucher disease were assayed retrospectively before and 16-22 months after institution of enzyme therapy with imiglucerase and when the principal manifestations of the disease had regressed. The values for each patient were determined without prior knowledge of treatment status and are depicted by individual symbols. Cathepsins B, K, and S are shown in panels A, B, and C, respectively.