Northern blot analysis showing up-regulation of cathepsin B, K, and S transcripts in Gaucher spleen.

Up-regulation of cathepsins B, K, and S is shown in panels A, B, and C, respectively. After washing, the filters were rehybridized to (A) mouse β-actin or (B and C) human glyceraldehyde phosphate dehydrogenase cDNA probes that serve as loading controls, as shown. The figure is a radioautograph and depicts signals obtained from spleen samples independent of those used to generate the Gaucher-specific cDNA library.