Effects of genotoxic drugs on GrB and PFN expression.

Flow cytometry analysis of cytotoxic drug-induced GrB and PFN expression as determined on KG1a cells. Cells were treated or not with 40 μmol/L AraC, 20 μmol/L VP-16, or 1 μmol/L DNR. Experiments were performed by flow cytometry with specific anti-GrB (white histograms) or anti-PFN (black histograms) MoAbs. Each histogram is the mean of five different experiments and is expressed relative to controls (au: arbitrary units). *P < .05.