Distribution of scuPA and scuPA/suPAR in vivo.

(A) Clearance of ¹²⁵I-scuPA from mouse blood. uPA^−/− mice were injected with 0.1 mg/kg¹²⁵I-scuPA (○) or ¹²⁵I-scuPA/suPAR (●), and the radioactivity in the blood of each mouse was measured at the indicated times. The results show the mean plus or minus SD of 3 mice studied serially. (B) Accumulation of ¹²⁵I-scuPA in pulmonary tissue. We infused uPA^−/− mice with 0.125 mg/kg/h ¹²⁵I-scuPA (■) or ¹²⁵I-scuPA /suPAR (□) for 1 hour. The isolated lungs were washed, and the radioactivity was measured. The results shown represent the mean plus or minus SEM of 2 experiments, each involving 3 mice. M.E. indicates microemboli.