Fig. 5.
Fig. 5. Effect of analogues of homocysteine and other thiol compounds on the expression of tissue factor by PBMC. / (A) Homocysteine analogues. Each compound is used at a final concentration of 100 μmol/L; the response to LPS (100 ng/mL) is shown for comparison. Results shown are the geometric mean ± SEM of the thromboplastin activity of PBMC from 3 donors. Statistical comparisons shown are by Scheffé test. +P  <  .01 compared to buffer control; *P  <  .01 compared to homocysteine. HCY,DL-homocysteine; HCY thiol, L-homocysteine thiolactone hydrochloride; Homocystine, L-homocystine; Cysteine, L-cysteine; 2-ME, 2-mercaptoethanol. (B) Dose response to various thiol compounds. Results shown are the geometric mean ± SEM of the thromboplastin activity of triplicate samples of PBMC from 1 donor.

Effect of analogues of homocysteine and other thiol compounds on the expression of tissue factor by PBMC.

(A) Homocysteine analogues. Each compound is used at a final concentration of 100 μmol/L; the response to LPS (100 ng/mL) is shown for comparison. Results shown are the geometric mean ± SEM of the thromboplastin activity of PBMC from 3 donors. Statistical comparisons shown are by Scheffé test. +P  <  .01 compared to buffer control; *P  <  .01 compared to homocysteine. HCY,DL-homocysteine; HCY thiol, L-homocysteine thiolactone hydrochloride; Homocystine, L-homocystine; Cysteine, L-cysteine; 2-ME, 2-mercaptoethanol. (B) Dose response to various thiol compounds. Results shown are the geometric mean ± SEM of the thromboplastin activity of triplicate samples of PBMC from 1 donor.

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