Expression of clusterin in primary lymphoid neoplasms.

Western analysis of representative lymphoid neoplasms was performed using a clusterin antibody specific to the α subunit. High-level expression of clusterin is detected in the 3 primary ALCL cases (ALCL 1-3); none or lesser amounts are seen in 3 representative cases of CLL (CLL 1-3). The limited expression of clusterin seen in the non-ALCL cases is presumably derived from trapped serum or from residual dendritic cells present in the biopsy specimens. High-level expression of clusterin is also seen in a reactive lymph node (FH1), showing marked follicular hyperplasia with accompanying follicular dendritic cell proliferation.