Expression of clusterin in representative primary lymphoid neoplasms.

Immunohistochemistry was performed using the anticlusterin antibody. (A) and (B) Two anaplastic large cell lymphomas, positive for clusterin. Note the strong characteristic Golgi staining (original magnification × 400). (C) Peripheral T-cell lymphoma, negative for clusterin (original magnification × 400). (D) Nasal NK/T cell lymphoma, negative for clusterin (original magnification × 400). (E) Nodular sclerosis Hodgkin disease (original magnification × 200). Reed-Sternberg cells and variants are negative for clusterin (arrows). Residual dendritic cells or fibroblastic reticulum cells are positive. (F) Reactive lymphoid hyperplasia (original magnification × 100). A reactive follicle shows intense staining of dendritic cells with weaker staining of interfollicular reticular cells. Normal B and T lymphocytes show no staining.