Structure of the terminal region (approximately 300 kb) of the human chromosome 16p.
The oval on the left represents the telomere. Previously described genes (4-203) are shown as black boxes above the line (transcribed toward the centromere) or below the line (transcribed toward the telomere). The α-globin regulatory element is shown as a white box (approximate coordinates 103 500-103 850). The embryonic (ζ) and fetal/adult (α) genes are indicated. Below the chromosome, the positions of previously characterized DNaseI hypersensitive sites (DHSs) and CpG islands (labeled A-N) are shown. Below this is a graph of the percent ofAlu sequences per 3 kb. Dashed vertical lines represent the 5′ and 3′ extents of the ZF deletion. The scale is in base pairs. Coordinate 1 is the first nucleotide in the chromosomal sequence described in Flint et al.3
