Serum immunoglobulin levels during sequential cycles of chemotherapy, PBPC infusions, and after completion of therapy.

Shaded areas represent 95% confidence intervals for normal values. All available immunoglobulin levels from the initial cohort of 19 patients are shown. Evaluation of immunoglobulin levels was discontinued at the time of tumor recurrence, therefore these data points represent various, rather than consistent, subjects over time. Asterisks denote median values that are significantly reduced from baseline using the paired sign rank test (P < .05). The time points noted as 1 to 30 months represent time after completion of PBPC-supported chemotherapy. Patients received 1 to 3 PBPC cycles as detailed in Table1. Pre-rx n = 18, Cy3 n = 13, PBPC1 n = 15, PBPC2 n = 11, PBPC3 n = 11, 1 month n = 13, 3 months n = 8, 6 months n = 7, 9 months n = 8, 12 months n = 6, 15 to 18 months n = 4, and 24 months n = 2.