BCL-6 mutations in FCL transformation.

Schematic representation of the BCL-6 5′ noncoding region mutations in molecular clones derived from FCL diagnosis biopsy specimen (A) and transformation to DLBCL biopsy specimen (B) from representative IL116 case, demonstrating intraclonal diversification at diagnosis and acquisition of new mutations in DLBCL biopsy specimens. Each sequence is represented as a horizontal line. The first nucleotide of the amplified BCL-6 gene region, corresponding to the first nucleotide of the sense primer, is arbitrarily defined as position +1. In each sequence, mutations are indicated as circles. The nature of each mutation is specified in Table1.