Receptor dependency of heparin-enhanced adhesion on HDMEC.

IE adherence to resting (□) and TNF-activated HDMEC (▪) was examined in the presence of 100 μg/mL heparin by using anti-CD36 8A6 and anti–ICAM-1 15.2 monoclonal antibodies (mAbs) to block specific engagement of one or both CD36 and ICAM-1 receptors. Binding was compared with a control from which heparin was absent. Results are the mean ± SD value for triplicate points from 1 of 2 experiments.