Characterization of the intracellular mechanism(s) by which SDF-1 and MDC activate platelets in PRP.

The figure demonstrates the ability of 500 μmol/L aspirin to inhibit the secondary wave of plasma platelet aggregation stimulated by 100 nmol/L (A) MDC (B) or SDF-1. The inclusion of the ADP scavenger, 10 mmol/L creatine phosphate, plus 10 U/mL creatine phosphokinase (CP/CPK) inhibits platelet activation stimulated by (C) 100 nmol/L MDC but not by (D) 100 nmol/L SDF-1.