Effects of recombinant human MIP-1 on OCL formation in human marrow cultures

. Human marrow cultures were processed as described in “Materials and methods.” MIP1-α significantly stimulated OCL formation in human bone marrow cultures when tested at concentrations of 100 to 200 pg/mL. Results represent the mean ± SEM of quadruplicate determinations for a typical experiment. A similar pattern of results was seen in 4 independent experiments.