Thrombus generation in platelet reconstituted thrombocytopenic PAI-1^+/+ and PAI-1^−/−mice.

Cumulative thrombus formation over 40 minutes after a 3-minute carotid artery photochemical injury, expressed as total light intensity;^+/+: wild-type mice;^−/−: PAI-1–deficient homozygotes. Thrombocytopenia was induced with busulfan in the groups indicated; mice were reconstituted with 5 × 10⁸ PAI-1^+/+ or PAI-1^−/− platelets and thrombosis was quantitated after injury induction. Data are the mean ± SEM for the number of mice indicated in parentheses. *P < .01 by Tukey-Kramer multiple comparison test in comparison with the groups indicated by the horizontal brackets; †P < 05.