Thrombus generation in PAI-1^+/+, PAI-1^+/−, and PAI-1^−/− mice.

Cumulative thrombus formation over 40 minutes after a 3-minute carotid artery photochemical injury, expressed as total light intensity;^+/+: wild-type mice; ^+/−: PAI-1 heterozygotes;^−/−: PAI-1–deficient homozygotes; thrombus formation in PAI-1^−/−mice after an intravenous bolus (35 ng) with recombinant murine PAI-1, administered immediately after photochemical injury, followed by continuous infusion (76 ng/h) for 40 minutes via an intravenous catheter (n = 6). Data are the mean ± SEM for the number of mice indicated in parentheses. *P < .01 by Dunnett multiple comparison test and †P < .05.