American Society of Hematology

Fig. 3.

$Fig. 3. Cytotoxicity of transduced and unmodified T cells after activation with allogeneic EBV BLCL. / Purified T cells of donor S.B. were stimulated with fully MHC-mismatched allogeneic BLCLs of donor M.A. MA-BLCL, not recognized by the NIT+ T-cell fraction after stimulation with autologous BLCLs of S.B., exhibited strong reactivity against EBV BLCL and PHA blasts of M.A., after initiation and restimulation with the allogeneic BLCLs and gene transfer on day 8 as described, showing the preferential selection of anti-allogeneic T cells. The corresponding anti-allo frequencies are described in Table 3.$

Cytotoxicity of transduced and unmodified T cells after activation with allogeneic EBV BLCL.

Purified T cells of donor S.B. were stimulated with fully MHC-mismatched allogeneic BLCLs of donor M.A. MA-BLCL, not recognized by the NIT⁺ T-cell fraction after stimulation with autologous BLCLs of S.B., exhibited strong reactivity against EBV BLCL and PHA blasts of M.A., after initiation and restimulation with the allogeneic BLCLs and gene transfer on day 8 as described, showing the preferential selection of anti-allogeneic T cells. The corresponding anti-allo frequencies are described in Table 3.

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