Skin biopsy specimens.

Skin biopsies were obtained from patient 2 just before (A) and 2 weeks after (B) treatment with the IT combination. The appearance of the skin before treatment is typical for severe GVHD. A scattered infiltration of lymphocytes can be observed, localized primarily around the blood vessels and the junctional region of dermis (lower side) and epidermis (upper side). The epidermal basal layer is destroyed and the epidermis is disrupted from the basal lamina. Following treatment, no remaining signs of lymphocyte infiltrations were detectable. The basal layer had regained its natural well-organized configuration (original magnification × 100, hematoxylin-eosin).