Fig. 2.
Reduction of CTL cytotoxicity by native MoAb SPV-T3a.
An EBNA3C-reactive CTL clone was incubated with 10−8mol/L MoAb SPV-T3a (▴), isotype-matched irrelevant MoAb MOPC-141 (◍) or culture medium (▪) for 24 hours at 37°C. Subsequently cells were washed and cultured for another 72 hours in culture medium. CTL cytotoxicity was then assayed by specific lysis of a51Cr-loaded autologous EBV-LCL and expressed as percentage relative to maximum lysis by detergent. Data represent the mean ± SD of 3 experiments performed in triplicate.
