Results with CTX followed by endostatin.
NOD/SCID mice that received transplants of 10 × 106Namalwa cells intraperitoneally were given 3 courses of CTX (75 mg/kg) on days 3, 5, and 7 after transplantation and randomly assigned to receive 50 μg of endostatin (⧫) or PBS (▪) on days 15 to 19. In endostatin-treated mice, but not in PBS-treated mice, tumor growth was prevented as long as endostatin was administered. Moreover, administration of endostatin on days 25 to 29 after tumor regrowth induced significant tumor regression (P = .02 by pairedt test comparing tumor volume on day 25 with that on day 30). The dotted line indicates tumor growth in untreated controls (▴). Results are mean ± SD values for tumor volume (n = 6 per group). *P = .02 vs day 25.
