Fig. 1.
![Fig. 1. BPI inhibits proliferation of HUVECs. / (A) Proliferation was measured after 72 hours of culture in the presence of 0.18, 0.54, or 1.8 μmol/L BPI by analysis of [3H]-thymidine incorporation. (B) Cell death induced by BPI, PF4, or BSA, or after starvation by culture in the presence of low serum concentrations (1%), as determined by trypan blue exclusion. (C) Comparison of proliferation inhibition by BPI (n = 4) and PF4 (n = 9), plotted as percentage of thymidine incorporation under control conditions. In panel A and B, the results of 3 independent experiments performed in triplicate are shown (*P < .05).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/96/1/10.1182_blood.v96.1.176/4/bloo01332001x.jpeg?Expires=1724235894&Signature=ykc1~vl60VCtKHW1LS4pkvt6OMLeoLTFCfaD37xLhZ-vJmaO2uAYSBrNBBLCSNGxRddOG3NFnxHAU3ha7RmDD3Dn9~IA8DfRY5IwfNp-6NKdP1ym9pLLlfids6-XKvbl21TZnC2nthpnjgfHpRU-mkL35bE65iQjFtNtiEyi9SxFi7HD7wpBLPCMY9DWKE3MUU8Cv~wtilNekAmFlSZHyhBx6Zqv8sj8RPkEMkpHry9Z14Erz9zrXO3pJ~cr7luA7VWXiHimW~dXG1Rei6IcgBkEmNosovcnYPHaP0pqNBxviZPpkSnrlx3wQG97s2a11SZOcLRTdlxjjtedYLB6nQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
BPI inhibits proliferation of HUVECs.
(A) Proliferation was measured after 72 hours of culture in the presence of 0.18, 0.54, or 1.8 μmol/L BPI by analysis of [3H]-thymidine incorporation. (B) Cell death induced by BPI, PF4, or BSA, or after starvation by culture in the presence of low serum concentrations (1%), as determined by trypan blue exclusion. (C) Comparison of proliferation inhibition by BPI (n = 4) and PF4 (n = 9), plotted as percentage of thymidine incorporation under control conditions. In panel A and B, the results of 3 independent experiments performed in triplicate are shown (*P < .05).
