American Society of Hematology

Fig. 7.

$Fig. 7. Effect of H2O2 on chemotherapy-induced apoptosis and phagocytosis of Burkitt lymphoma cells. / The Burkitt lymphoma cell lines JLP 119, BL-41, and ST-486 were treated for 4 hours with VP-16 (8.5, 340, or 85 μmol/L, respectively) in the presence or absence of 75 μmol/L H2O2 and then subjected to phagocytosis by human monocyte-derived macrophages, as described in “Materials and methods.” The fractions of cells dying by apoptosis, pyknosis/necrosis, or typical necrosis are shown in the top row of graphs. Percent phagocytosis for these cell populations is shown in the lower row of graphs. The results represent the mean ± range or SD for 2 to 3 separate experiments for JLP 119 and ST-486 cells. The data for BL-41 represent 1 experiment.$

Effect of H₂O₂ on chemotherapy-induced apoptosis and phagocytosis of Burkitt lymphoma cells.

The Burkitt lymphoma cell lines JLP 119, BL-41, and ST-486 were treated for 4 hours with VP-16 (8.5, 340, or 85 μmol/L, respectively) in the presence or absence of 75 μmol/L H₂O₂ and then subjected to phagocytosis by human monocyte-derived macrophages, as described in “Materials and methods.” The fractions of cells dying by apoptosis, pyknosis/necrosis, or typical necrosis are shown in the top row of graphs. Percent phagocytosis for these cell populations is shown in the lower row of graphs. The results represent the mean ± range or SD for 2 to 3 separate experiments for JLP 119 and ST-486 cells. The data for BL-41 represent 1 experiment.

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