DNA histograms of Bcl-2-AS- or NS-treated leukemic cells from 3 AML samples.

Cellular DNA content was measured by acridine orange as described in “Materials and methods.” The curve fitting software (ModFit) allowed the determination of the percentage of cells in different phases of cell cycle. In all samples shown, S-phase increased in Bcl-2-AS–treated samples, compared with NS controls.