Bcl-2-AS increased sensitivity to ara-C in both HL-60 and in HL-60-DOX cells.

Combined effect of Bcl-2-AS and ara-C on the growth of leukemic cell lines was tested using the MTS assay after 72 hours of treatment. Note that higher concentrations of Bcl-2-AS were required in HL-DOX cells because they expressed higher levels of Bcl-2.