Changes in serum levels of FDP(E) in rats that had renal I/R, and effects of APC, DEGR-FXa, heparin, DIP-APC, and leukocytopenia on I/R-induced increases in serum levels of FDP(E) 24 hours after reperfusion.

(A) Rats were subjected to uninephrectomy and 60 minutes of renal ischemia followed by reperfusion. Serum levels of FDP(E) were measured before ischemia (Pre), and 3, 6, 12, 24, and 48 hours after reperfusion. Rats in the sham-operation group had uninephrectomy only. Data are expressed as mean ± SD values. Open circles indicate rats in the sham-operation group (n = 5); and closed circles, rats that had I/R (n = 5). *P < .01 compared with the sham-operation group. (B) Rats were given intravenously administered saline, APC (100 μg/kg), DEGR-FXa (1 mg/kg), heparin (300 U/kg), or DIP-APC (100 μg/kg) 30 minutes before reperfusion. Leukocytopenia was induced by administration of nitrogen mustard. Data are expressed as mean ± SD values. Values in parentheses indicate the number of animals in each experiment. *P < .01 compared with the sham-operation group; †P < .01 compared with the I/R plus saline group.