Effects of APC, DEGR-FXa, heparin, DIP-APC, and leukocytopenia on I/R-induced increases in BUN and creatinine.

Serum levels of BUN (A) and creatinine (B) were measured 24 hours after reperfusion in rats subjected to 60 minutes of renal ischemia followed by reperfusion. Animals were intravenously administered saline, APC (100 μg/kg of body weight), DEGR-FXa (1 mg/kg), heparin (300 U/kg), or DIP-APC (100 μg/kg) 30 minutes before reperfusion. Leukocytopenia was induced by administration of nitrogen mustard. Data are expressed as mean ± SD values. Values in parentheses indicate the number of animals in each experiment. *P < .01 compared with the sham-operation group; †P < .01 compared with the I/R plus saline group.