Oral administration of KF41399 induced G₀/G₁ arrest of MNC and Lin⁻cells in mice.

Mice were treated with 25 mg/kg KF41399 orally twice daily for 3 days (protocol B, Table 1). Control animals were administered distilled water instead of KF41399. MNC and Lin⁻ cells were prepared on day 3, cell cycle distribution was analyzed by FACScan, and CFC activity was analyzed as described in “Materials and methods.” KF41399 induced G₀/G₁ arrest of MNC (A) and Lin⁻ cells (B). Data shown are representative of at least 3 independent experiments. KF41399 effects on CFC activity of MNC (C). Results are expressed as the mean ± SD. n = 5 in each group.