Fig. 7.
Fig. 7. Model of the proposed mechanism causing the prevalentRHD− haplotypes in whites. / (A) The physical structure of the RHD and RHCE gene locus. (B) An unequal crossing-over between the upstream and downstreamRhesus boxes can be triggered by their high homology. The breakpoint region in the Rhesus boxes was found to be of 100% homology for 903 bp (Figure 5). (C) Resolving the crossed-over chromosome yields the RH gene structure of the extant RHD−haplotype.

Model of the proposed mechanism causing the prevalentRHD− haplotypes in whites.

(A) The physical structure of the RHD and RHCE gene locus. (B) An unequal crossing-over between the upstream and downstreamRhesus boxes can be triggered by their high homology. The breakpoint region in the Rhesus boxes was found to be of 100% homology for 903 bp (Figure 5). (C) Resolving the crossed-over chromosome yields the RH gene structure of the extant RHD−haplotype.

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