Nucleotide alignment of the REDK-L and REDK-S cDNA.

(A) The 5′-ends of the cDNA are shown, with nucleotides numbered according to the longest clone obtained. Initiation codons for REDK-L, REDK-S, and DYRK3 are in bold, as are upstream in-frame stop codons for REDK-L and REDK-S. Downstream sequences for REDK-L, REDK-S, and DYRK3 are identical and are not shown. (B) Translated amino acid sequences for REDK-L and REDK-S. Residues predicted to contribute to ATP binding are underlined. Active site catalytic residues are bold. The start of the DYRK3 product coincides with Met36 in REDK-L (designated by an asterisk).