Effect of age on CD95 expression on T-cell subsets.

The percentages and absolute numbers of CD95⁻ (○) and CD95⁺ (•) cells within both CD4 and CD8 T cells were plotted as individual data points from 71 subjects. R andP values were calculated by linear regression analysis. The percentage of CD95⁻ cells decreased with age, and symmetrically the percentages of CD95⁺ T cells increased with age in both the (A) CD4 subset and the (B) CD8 subset. (C, D) Considering absolute numbers, only CD95⁻CD4⁺ and CD95⁻CD8⁺ cells significantly declined. In contrast, the CD95⁺CD4⁺ and CD95⁺CD8⁺ cells did not change.