The effect of UIC2 on blast survival in pgp+ve and pgp−ve patient samples.

Primary AML cells were cultured in 1% FCS with UIC2 anti-pgp and isotype- and concentration-matched control antibodies. Flow cytometer dot-plots illustrate nonviable cells (high 7-AAD in FL3, decreased forward scatter) in (A) IgG2a and (B) UIC2-treated cells (patient RF). Numbers on plots are the percentages of nonviable cells.