Anti-p58 monoclonal antibody (mAb) inhibition of the cytolytic capacities of p58⁺ T cells.

(A) Lysis of tumor cells by p58⁺ and p58⁻T-cell lines and the p58⁺ cytotoxic T lymphocyte (CTL) clone 4C7. The cytotoxic activity of effector cells against autologous RCC was tested in a standard chromium-release assay at the indicated ratio of effector to target cells. Inhibition of the lytic activity was tested after preincubation of the cells for 30 minutes with the indicated mAbs. (B) CD3-redirected lysis of P815 cells induced by T-cell lines was generated by anti-CD3ε mAb (1 μg/mL) in the presence of anti-NK-R mAbs (2μg/mL).