Fig. 6.
![Fig. 6. Functional expression of the IE transgene on B cells from B6 CD19-IE mice induces antigen-specific proliferation in I-E restricted CD4 T cells. / B220-positive splenocytes from B6 and B6 CD19-IE animals were sorted, irradiated, and used as APC for preactivated T-cell blasts from AD10 TCR transgenic mice. The coculture was performed in the presence of graded amounts of antigenic peptide (MCC88-103), and proliferation was measured by [3H] thymidine incorporation.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/95/8/10.1182_blood.v95.8.2610/4/bloo00811006x.jpeg?Expires=1723227928&Signature=vcdwrojH5Yqp84csQ8ufHIjzpmEhr6wC2RXUHas6MdGkE5mDUjtxmuAFtmiNTK~SP4yVVobDuzlW-o6rvHJOGLwgE9BeYnSr0uN0igif6tXGpcrtuOVJooacS82QVZq5NEnxV9HC13XBWwCexoJZytl-g0~cW6DAlRYvJCPsuRy0~UM83YjreOONNytveRJiUuW0fko~Py4IsyMi7~1-Dc5-hV~bssQewyoGMcgpvM3UHPcC2ETL~8o0fDmwXFfk3sxT2kG7xbwDzXUJD0u11kpFGbo0qGkr-4Zabb7gbB8mU-~1-E1C4Y6FXf35AqvyvlDMuR1ZIZDStCglt4ILZQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Functional expression of the IE transgene on B cells from B6 CD19-IE mice induces antigen-specific proliferation in I-E restricted CD4 T cells.
B220-positive splenocytes from B6 and B6 CD19-IE animals were sorted, irradiated, and used as APC for preactivated T-cell blasts from AD10 TCR transgenic mice. The coculture was performed in the presence of graded amounts of antigenic peptide (MCC88-103), and proliferation was measured by [3H] thymidine incorporation.
